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The R package 'DeepGS' can be used to perform genomic selection (GS), which is a promising breeding strategy in plants and animals. DeepGS predicts phenotypes using genomewide genotypic markers with an advanced machine learning technique (deep learning). The effectiveness of DeepGS has been demonstrated in predicting eight phenotypic traits on a population of 2000 Iranian bread wheat (Triticum aestivum) lines from the wheat gene bank of the International Maize and Wheat Improvement Center (CIMMYT).